Cytosolic reducing power preserves glutamate in retina
نویسندگان
چکیده
منابع مشابه
Cytosolic reducing power preserves glutamate in retina.
Glutamate in neurons is an important excitatory neurotransmitter, but it also is a key metabolite. We investigated how glutamate in a neural tissue is protected from catabolism. Flux analysis using (13)C-labeled fuels revealed that retinas use activities of the malate aspartate shuttle to protect >98% of their glutamate from oxidation in mitochondria. Isolation of glutamate from the oxidative p...
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The main neurotransmitters in the vertebrate retina are glutamate, GABA and glycine. Their localization in the different cell types in the retina is well known. In addition, there exists a number of neuropeptides and other neuroactive substances that are only expressed by sparse populations of neurons. In recent years, molecular biology has led to the discovery of a rapidly increasing number of...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2013
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1311193110